This paper deals with the leading edge cavitation of the impeller of a single stage helico-centrifugal pump. In the one hand, in order to perform experimental investigations, a specific impeller with transparent shroud and a special casing with windows have been used as experimental test rig. The leading edge cavitation has been experimentally observed on the both sides of the impeller and the head drop measured for different operating conditions. In the other hand, a CFD model for cavitation simulation has been investigated and compared to experimental results for 3 flowrates, ranging from 0.85 Qn to 1.25 Qn. The model uses a multiphase approach, based on a homogeneous model assumption. A truncated form of Rayleigh-Plesset equation is used as a source term for the inter-phase mass transfer. Comparisons between experimental and numerical results are presented and the cavitation figures are in a good agreement with the experimental ones for each flowrate.